Re: Stanford Study Proves Covid-19 Was Overhyped...

by veber 1/5/2020, 13:12

Legendovich wrote:
kaya wrote:
Legendovich wrote:ajd ti yoda po tim vasim optimisticnim predvidjanjima,reci,hocul ja moci doli do kraja godine?..samo me to zanima..
Pa ti zapravo cijelo vrijeme možeš doli, nije mi poznato da je zabranjeno vratiti se u državu. Očito ne ideš iz drugog razloga
zapravo istina...ne mogu cekati dva tjedna u karanteni,a odjedared mi jave da moramo doci na posel..,i po povratku josh dva tjedna u svapskoj karanteni..

4 tjedna s rujkom.
tko to može platiti?

by Guest 1/5/2020, 13:25

Scientists feud over hyped Stanford coronavirus antibody study: “The authors owe us all an apology”

Study that says Silicon Valley cases were underestimated by 85x exemplifies "how NOT to do statistics", expert says

Many researchers around the country said the Santa Clara County study was simply flawed. The researchers used kits from the company Premier Biotech, which has one of the lower "false positive" rates but still shows "false positives" in two of every 371 true negative samples, according to the San Jose Mercury News.

"With that ratio of false positives, a large number of the positive cases reported in the study — 50 out of 3330 tests — could be false positives, critics note," the outlet reported. "To ensure a test is sensitive enough to pick up only true [coronavirus] infections, it needs to evaluate hundreds of positive cases of COVID-19 among thousands of negative ones."

The study was also criticized for recruiting volunteer test subjects on Facebook, which critics argued could have skewed the testing sample to people who believed they had been infected but were unable to get tested.

"I think the authors of the above-linked paper owe us all an apology," said Andrew Gelman, the director of the applied statistics center at Columbia University. "We wasted time and effort discussing this paper whose main selling point was some numbers that were essentially the product of a statistical error."

The study's authors told the Mercury News that they would release a detailed appendix that would address many of the "constructive comments and suggestions" that the researchers had received.

"This is exactly the way peer-review should work in scientific work, and we are looking forward to engaging with other scholars as we proceed in this important work," Bhattacharya told the outlet.

Ioannidis also said that an expanded version of the study would soon be posted and argued that "the results remain very robust."

But critics said the results, which have already been widely shared, were an example professors could teach to classes to "show how NOT to do statistics."

"They're the kind of screw-ups that happen if you want to leap out with an exciting finding," said Gelman, "and you don't look too carefully at what you might have done wrong."

"Do NOT interpret this study as an accurate estimate of the fraction of population exposed," warned Marm Kilpatrick, an infectious disease researcher at the University of California Santa Cruz. "Authors have made no efforts to deal with clearly known biases and whole study design is problematic."

The USC study, which used the same type of test, was criticized for broadcasting its results without describing its methodology. Los Angeles officials have already pegged their death rate at 0.2% based on the results, however, suggesting that the virus is twice as deadly as the flu but far less deadly than other estimates.

https://www.salon.com/2020/04/26/scientists-feud-over-hyped-stanford-coronavirus-antibody-study-the-authors-owe-us-all-an-apology/

by Counter-Strike 1/5/2020, 18:24

https://webtribune.rs/udarna-vest-szo-i-gejts-izgubili-ostaju-bez-desilo-se-jos-nesto-vazno/?fbclid=IwAR2T0LK8LDwJy6QvhfJ9nZW9E3MLBPKZlYGI767Rsx2hs1ZgGakhD_08MZ0

by Eroo 1/5/2020, 18:52

AssadNaPodmornici wrote:
Legendovich wrote:e to moli Boga da najesen se opet ne pojavi,jer ce to biti nesto posve drugo..mozda samo isti naziv..dotada bude prejebeno mutirao
možda i ne mutira toliko puno da bude pre-opasan.

Virus "ne želi" ubiti svoju žrtvu, jer mu žrtva treba za razmnožavanje.
Ako "procjeni" da je preopasan za svoje žrtve onda odbacuje jedne dijelove
iz svoga RNK, tako da bude manje opasan.
Pusti Svetoju, on je prestravljen pa traži supatnike.

by Guest 1/5/2020, 20:56

Eroo wrote:
AssadNaPodmornici wrote:
Legendovich wrote:e to moli Boga da najesen se opet ne pojavi,jer ce to biti nesto posve drugo..mozda samo isti naziv..dotada bude prejebeno mutirao
možda i ne mutira toliko puno da bude pre-opasan.
Virus "ne želi" ubiti svoju žrtvu, jer mu žrtva treba za razmnožavanje.
Ako "procjeni" da je preopasan za svoje žrtve onda odbacuje jedne dijelove
iz svoga RNK, tako da bude manje opasan.
Pusti Svetoju, on je prestravljen pa traži supatnike.

Pokusaj ponovno amateru.. :cleanteeth

Stanford Study Proves Covid-19 Was Overhyped... - Page 3 Ebola_11_slide-e76a57c936a559e97a9776436e4bde64ade62c77-s800-c85

by Guest 1/5/2020, 21:22

Eroo wrote:
AssadNaPodmornici wrote:
Legendovich wrote:e to moli Boga da najesen se opet ne pojavi,jer ce to biti nesto posve drugo..mozda samo isti naziv..dotada bude prejebeno mutirao
možda i ne mutira toliko puno da bude pre-opasan.
Virus "ne želi" ubiti svoju žrtvu, jer mu žrtva treba za razmnožavanje.
Ako "procjeni" da je preopasan za svoje žrtve onda odbacuje jedne dijelove
iz svoga RNK, tako da bude manje opasan.
Pusti Svetoju, on je prestravljen pa traži supatnike.

eh, kad bi to bila istina...ali nije:

Study Shows Of Spike Mutations Of SARS-CoV-2, Making It More Transmissible And Dangerous.The Reality Is That There Is Unlikely To Be A Vaccine

Disturbing news is emerging as research findings from a collaborative study involving medical, genomic and virology researchers from Los Alamos National Laboratory in New Mexico-US, University Of Sheffield-UK, Duke University in North Carolina-US, Sheffield Teaching Hospital-UK and the NHS-Foundation-UK, show that the Spike elements of SARS-CoV-2 coronavirus is mutating in a manner that indicates it is evolving to become stronger and more easily transmissible to humans and at the same time becoming more clinically harmful to humans.

Spike mutation pipeline reveals the emergence of a more transmissible form of SARS-CoV-2

https://www.biorxiv.org/content/10.1101/2020.04.29.069054v1

The pre-print release which is being reviewed for publication into a journal, focused on real-time mutation tracking in the SARS-CoV-2 coronavirus, specifically on the Spike (S) protein because it mediates infection of human cells and is the target of most vaccine strategies and antibody-based therapeutics.

The Team studied the mutations taking place across the Spike protein regions of the SARS-CoV-2 coronavirus over the last two months monitoring changes from the early strains in Wuhan to the specific strains across the globe in conjunction with the GISAID data.

They focused on 14 specific sites on the virus and 2 Spike mutations were of particular interests: D614G and S943P.

It was found that D614G is increasing in frequency at an alarming rate, indicating a fitness advantage relative to the original Wuhan strain and enables more rapid spread. S943P is located in the fusion core region, and is of particular interest as it is concerned with spreading via recombination.

The mutation D614G (a G-to-A base change at position 23,403 in the Wuhan reference strain) was the only site of interests to the researchers as it was found 7 times in 183 sequences that were available at the time. Four of these seven first D614G strains were sampled in Europe, and one each in Mexico, Brazil, and in Wuhan. In 5/7 cases, D614G was accompanied by 2 other mutations: a silent C-to-T mutation in the nsp3 gene at position 3,037, and a C-to-T mutation at position 14,409 which results in a RNA-dependent RNA polymerase (RdRp) amino acid change (RdRp P323L).The combination of these three mutations forms the basis for the clade that soon emerged in Europe.

In mid-March, D614G was being tracked at the GISAID due to its high frequency, and referred to as the “G” clade; it was present in 29% of the global samples, but was still found almost exclusively in Europe.

However, an early April sampling of the data from GISAID showed that G614’s frequency was increasing at an alarming pace throughout March, and it was clearly showing an ever-broadening geographic spread.

A clear and consistent pattern was observed in almost every place where adequate sampling was available. In most countries and states where the COVID-19 epidemic was initiated and where sequences were sampled prior to March 1, the D614 form was the dominant local form early in the epidemic.

Wherever G614 entered a population, a rapid rise in its frequency followed, and in many cases G614 became the dominant local form in a matter of only a few weeks.

In Europe, where the G614 first began its expansion, the D614 and G614 forms were circulating early in the epidemic, with D614 more common in most sampled countries, the exceptions being Italy and Switzerland.

Through March, G614 became increasingly common throughout Europe, and by April it dominated contemporary sampling. In North America, infections were initiated and established across the continent by the original D614 form, but in early March, the G614 was introduced into both Canada and the USA, and by the end of March it had become the dominant form in both nations. Washington state, the state with the greatest number of available GISAID SARS-CoV-2 sequences from the USA, exemplifies this pattern (Figure 3 and S3), and a similar shift over time is evident in many other states including New York.

From a genomic and virological aspect, the D614G mutation is associated with increased transmission. The first is based on structure. D614 is located on the surface of the spike protein protomer, where it can form contacts with the neighboring protomer. The mutation allows from a structurally perspective more easy ‘binding’ to human host cells through a variety of ways and from a immunological function, it disrupts antibody functions trying to attack it.

Hence the D614G mutation not only increases transmissibility, but also impacts severity of disease.

The S943P mutation however allows recombinant strategies for the virus to evolve.

The study of the other mutation sites L5F, L8V V367F, G476S, and V483A all indicate that he virus can easily and evolve depending and conditions, displaying characteristics that it is even far more potent than HIV. There were also many other sites of mutations that the study covered.

https://www.thailandmedical.news/news/breaking-covid-19-warning-study-shows-of-spike-mutations-of-sars-cov-2,-making-it-more-transmissible-and-dangerous-the-reality-is-that-there-is-unlike

by Guest 1/5/2020, 21:26

ne kuzim zasto ero,tako blebece,kad ga najobicnija wiki pretraga,da ne spominjem strucne izvore,mogu doslovno posrati po glavi...ali hajde..svakom njegov "ćeif"

by Guest 1/5/2020, 21:30

Legendovich wrote:ne kuzim zasto ero,tako blebece,kad ga najobicnija wiki pretraga,da ne spominjem strucne izvore,mogu doslovno posrati po glavi...ali hajde..svakom njegov "ćeif"

dokument i rezultati istraživanja su objavljeni jučer Posted April 30, 2020

a kad ero nešto tvrdi budi siguran da će se desiti upravo suprotno.

by Eroo 1/5/2020, 21:37

T. wrote:To je stara đikićeva izjava...
U meduvremenu se priklonio katastrofičarima i počeo zagovarati globalno cijepljenje...
'Sve je na prodaju i svatko ima svoju cijenu'...

Ako reprodukcijski koeficient R s mjerama svedeš pod 1 onda se virus sam od sebe uguši.
Đikić je u početku bio u pravu jer je tada R bio između 3 i 4.
Netko (Capak? Alemka?) prije cca tjedan dana da je R u HR 0,8 (valjda podatak objavio WHO ili tko već).
Danas je po županijama broj nanovo zaraženih bio redom nula, osim u splitsko-dalmatnskoj.
Ovako može potrajati sve dok budete imali zatvorene granice. No, to neće biti tako, jer tako se ne može naprijed.

by Eroo 1/5/2020, 21:40

Gnječ wrote:
Legendovich wrote:ne kuzim zasto ero,tako blebece,kad ga najobicnija wiki pretraga,da ne spominjem strucne izvore,mogu doslovno posrati po glavi...ali hajde..svakom njegov "ćeif"

dokument i rezultati istraživanja su objavljeni jučer Posted April 30, 2020

a kad ero nešto tvrdi budi siguran da će se desiti upravo suprotno.

Epidemija je u HR zaustavljena 14.4., kao što sam i prognozirao.
Moja nova prognoza je bila: decrescendo do 7.5.-og i diminuendo do 14.5.-og.
Samo prati, Gnječo.

by Guest 1/5/2020, 21:50

Eroo wrote:
Gnječ wrote:
Legendovich wrote:ne kuzim zasto ero,tako blebece,kad ga najobicnija wiki pretraga,da ne spominjem strucne izvore,mogu doslovno posrati po glavi...ali hajde..svakom njegov "ćeif"

dokument i rezultati istraživanja su objavljeni jučer Posted April 30, 2020

a kad ero nešto tvrdi budi siguran da će se desiti upravo suprotno.
Epidemija je u HR zaustavljena 14.4., kao što sam i prognozirao.
Moja nova prognoza je bila: decrescendo do 7.5.-og i diminuendo do 14.5.-og.
Samo prati, Gnječo.

ne pratim te. ti nisi pouzdan izvor informacija još si u stadiju poricanja tj.denial.

by Guest 1/5/2020, 21:52

Gnječ wrote:
Legendovich wrote:ne kuzim zasto ero,tako blebece,kad ga najobicnija wiki pretraga,da ne spominjem strucne izvore,mogu doslovno posrati po glavi...ali hajde..svakom njegov "ćeif"

dokument i rezultati istraživanja su objavljeni jučer Posted April 30, 2020

a kad ero nešto tvrdi budi siguran da će se desiti upravo suprotno.

by Guest 1/5/2020, 21:54

Odlican teks Gnječo..Ero savjetujem da ga procitas...

by Guest 1/5/2020, 21:59

naravno,Kaye nema u skoli,a kasnije ce samo treptati okicama i cuditi se svemu..
Ovo se podudara sa dosadasnjom teorijom da ce drugi treci val viruza biti opakiji i smrtonisniji..
Ovi koji su vec prilicno poharani u prvom valu,imaju sigurnu kartu za valhalu..

by Guest 1/5/2020, 22:00

ovaj ling je inace odlicna stvar..

https://www.thailandmedical.news/news/breaking-covid-19-warning-study-shows-of-spike-mutations-of-sars-cov-2,-making-it-more-transmissible-and-dangerous-the-reality-is-that-there-is-unlike

by Guest 1/5/2020, 22:22

Gnječ wrote:
Eroo wrote:
AssadNaPodmornici wrote:
Legendovich wrote:e to moli Boga da najesen se opet ne pojavi,jer ce to biti nesto posve drugo..mozda samo isti naziv..dotada bude prejebeno mutirao
možda i ne mutira toliko puno da bude pre-opasan.
Virus "ne želi" ubiti svoju žrtvu, jer mu žrtva treba za razmnožavanje.
Ako "procjeni" da je preopasan za svoje žrtve onda odbacuje jedne dijelove
iz svoga RNK, tako da bude manje opasan.
Pusti Svetoju, on je prestravljen pa traži supatnike.

eh, kad bi to bila istina...ali nije:

Study Shows Of Spike Mutations Of SARS-CoV-2, Making It More Transmissible And Dangerous.The Reality Is That There Is Unlikely To Be A Vaccine

Disturbing news is emerging as research findings from a collaborative study involving medical, genomic and virology researchers from Los Alamos National Laboratory in New Mexico-US, University Of Sheffield-UK, Duke University in North Carolina-US, Sheffield Teaching Hospital-UK and the NHS-Foundation-UK, show that the Spike elements of SARS-CoV-2 coronavirus is mutating in a manner that indicates it is evolving to become stronger and more easily transmissible to humans and at the same time becoming more clinically harmful to humans.

Spike mutation pipeline reveals the emergence of a more transmissible form of SARS-CoV-2

https://www.biorxiv.org/content/10.1101/2020.04.29.069054v1

The pre-print release which is being reviewed for publication into a journal, focused on real-time mutation tracking in the SARS-CoV-2 coronavirus, specifically on the Spike (S) protein because it mediates infection of human cells and is the target of most vaccine strategies and antibody-based therapeutics.

The Team studied the mutations taking place across the Spike protein regions of the SARS-CoV-2 coronavirus over the last two months monitoring changes from the early strains in Wuhan to the specific strains across the globe in conjunction with the GISAID data.

They focused on 14 specific sites on the virus and 2 Spike mutations were of particular interests: D614G and S943P.

It was found that D614G is increasing in frequency at an alarming rate, indicating a fitness advantage relative to the original Wuhan strain and enables more rapid spread. S943P is located in the fusion core region, and is of particular interest as it is concerned with spreading via recombination.

The mutation D614G (a G-to-A base change at position 23,403 in the Wuhan reference strain) was the only site of interests to the researchers as it was found 7 times in 183 sequences that were available at the time. Four of these seven first D614G strains were sampled in Europe, and one each in Mexico, Brazil, and in Wuhan. In 5/7 cases, D614G was accompanied by 2 other mutations: a silent C-to-T mutation in the nsp3 gene at position 3,037, and a C-to-T mutation at position 14,409 which results in a RNA-dependent RNA polymerase (RdRp) amino acid change (RdRp P323L).The combination of these three mutations forms the basis for the clade that soon emerged in Europe.

In mid-March, D614G was being tracked at the GISAID due to its high frequency, and referred to as the “G” clade; it was present in 29% of the global samples, but was still found almost exclusively in Europe.

However, an early April sampling of the data from GISAID showed that G614’s frequency was increasing at an alarming pace throughout March, and it was clearly showing an ever-broadening geographic spread.

A clear and consistent pattern was observed in almost every place where adequate sampling was available. In most countries and states where the COVID-19 epidemic was initiated and where sequences were sampled prior to March 1, the D614 form was the dominant local form early in the epidemic.

Wherever G614 entered a population, a rapid rise in its frequency followed, and in many cases G614 became the dominant local form in a matter of only a few weeks.

In Europe, where the G614 first began its expansion, the D614 and G614 forms were circulating early in the epidemic, with D614 more common in most sampled countries, the exceptions being Italy and Switzerland.

Through March, G614 became increasingly common throughout Europe, and by April it dominated contemporary sampling. In North America, infections were initiated and established across the continent by the original D614 form, but in early March, the G614 was introduced into both Canada and the USA, and by the end of March it had become the dominant form in both nations. Washington state, the state with the greatest number of available GISAID SARS-CoV-2 sequences from the USA, exemplifies this pattern (Figure 3 and S3), and a similar shift over time is evident in many other states including New York.

From a genomic and virological aspect, the D614G mutation is associated with increased transmission. The first is based on structure. D614 is located on the surface of the spike protein protomer, where it can form contacts with the neighboring protomer. The mutation allows from a structurally perspective more easy ‘binding’ to human host cells through a variety of ways and from a immunological function, it disrupts antibody functions trying to attack it.

Hence the D614G mutation not only increases transmissibility, but also impacts severity of disease.

The S943P mutation however allows recombinant strategies for the virus to evolve.

The study of the other mutation sites L5F, L8V V367F, G476S, and V483A all indicate that he virus can easily and evolve depending and conditions, displaying characteristics that it is even far more potent than HIV. There were also many other sites of mutations that the study covered.

https://www.thailandmedical.news/news/breaking-covid-19-warning-study-shows-of-spike-mutations-of-sars-cov-2,-making-it-more-transmissible-and-dangerous-the-reality-is-that-there-is-unlike

by veber 1/5/2020, 22:26

Legendovich wrote:naravno,Kaye nema u skoli,a kasnije ce samo treptati okicama i cuditi se svemu..
Ovo se podudara sa dosadasnjom teorijom da ce drugi treci val viruza biti opakiji i smrtonisniji..
Ovi koji su vec prilicno poharani u prvom valu,imaju sigurnu kartu za valhalu..

a kaj se ti pališ na kayu?
pošalji ženi pp.
možda odgovori, možda ne.
pol foruma se uzjebalo na nju.
pošalješ pp ili će ti odgovorit ili neće.
šanse ti lapo/lapo lus jedan.

by Guest 1/5/2020, 22:37

veber wrote:
Legendovich wrote:naravno,Kaye nema u skoli,a kasnije ce samo treptati okicama i cuditi se svemu..
Ovo se podudara sa dosadasnjom teorijom da ce drugi treci val viruza biti opakiji i smrtonisniji..
Ovi koji su vec prilicno poharani u prvom valu,imaju sigurnu kartu za valhalu..
a kaj se ti pališ na kayu?
pošalji ženi pp.
možda odgovori, možda ne.
pol foruma se uzjebalo na nju.
pošalješ pp ili će ti odgovorit ili neće.
šanse ti lapo/lapo lus jedan.

hahahaha..ono..Kaya je simpa ali nije moj tip cure..gledam je kao malo neposlusnu i tvrdoglavu sestricu..
ne brini,sva je tvoja.. :love

by veber 1/5/2020, 22:44

Legendovich wrote:
veber wrote:
Legendovich wrote:naravno,Kaye nema u skoli,a kasnije ce samo treptati okicama i cuditi se svemu..
Ovo se podudara sa dosadasnjom teorijom da ce drugi treci val viruza biti opakiji i smrtonisniji..
Ovi koji su vec prilicno poharani u prvom valu,imaju sigurnu kartu za valhalu..
a kaj se ti pališ na kayu?
pošalji ženi pp.
možda odgovori, možda ne.
pol foruma se uzjebalo na nju.
pošalješ pp ili će ti odgovorit ili neće.
šanse ti lapo/lapo lus jedan.
hahahaha..ono..Kaya je simpa ali nije moj tip cure..gledam je kao malo neposlusnu i tvrdoglavu sestricu..
ne brini,sva je tvoja..

gle. vaše projekcije nemaju veze s stvarnošću.
ja živim ionako s drugom ženom. mi se malo dopisujemo a, ti odmah misliš da je kaya "moja"
javi joj na pp broj i možda ti se javi.

by Eroo 1/5/2020, 23:11

Gnječ wrote:
Eroo wrote:
Gnječ wrote:
Legendovich wrote:ne kuzim zasto ero,tako blebece,kad ga najobicnija wiki pretraga,da ne spominjem strucne izvore,mogu doslovno posrati po glavi...ali hajde..svakom njegov "ćeif"

dokument i rezultati istraživanja su objavljeni jučer Posted April 30, 2020

a kad ero nešto tvrdi budi siguran da će se desiti upravo suprotno.
Epidemija je u HR zaustavljena 14.4., kao što sam i prognozirao.
Moja nova prognoza je bila: decrescendo do 7.5.-og i diminuendo do 14.5.-og.
Samo prati, Gnječo.

ne pratim te. ti nisi pouzdan izvor informacija još si u stadiju poricanja tj.denial.

Ne pratiš me ali znaš da sam nepouzdan. Sasvim pouzdan, jer se uz matematiku držim i prirodnih zakona.
Evo, na primjer, čitam u tim pustim istraživanjima gdje kažu:
Na temelju preliminarnih istraživanja zaključujemo da je reprodukcijski faktor virusa Ro između 1,5 i 3,5.
Da su uz sve znanje i trud poštovali poznate zakone u prirodi (PHI, u ovom slučaju) onda su mogli reći Ro = 1.618 do 3.628.
Svetoja ovo neće skužiti, ali predpostavljam da ti hoćeš.Aj'mu ti oprobaj bjasniti, meni se neda.

by **Hektorović** 2/5/2020, 07:00

Gnječ wrote:
Eroo wrote:
AssadNaPodmornici wrote:
Legendovich wrote:e to moli Boga da najesen se opet ne pojavi,jer ce to biti nesto posve drugo..mozda samo isti naziv..dotada bude prejebeno mutirao
možda i ne mutira toliko puno da bude pre-opasan.
Virus "ne želi" ubiti svoju žrtvu, jer mu žrtva treba za razmnožavanje.
Ako "procjeni" da je preopasan za svoje žrtve onda odbacuje jedne dijelove
iz svoga RNK, tako da bude manje opasan.
Pusti Svetoju, on je prestravljen pa traži supatnike.

eh, kad bi to bila istina...ali nije:

Study Shows Of Spike Mutations Of SARS-CoV-2, Making It More Transmissible And Dangerous.The Reality Is That There Is Unlikely To Be A Vaccine

Jasno, stvar je puno opasnija nego što neki žele priznati.

Dodatni problem su dugoročni komorbiditeti, još ne znamo šta će biti sa ljudima koju su preboljeli, koliko će se izraziti šteta na organizam.

by Sponsored content