Re: Korona novosti i spoznaje

by mutava baštarda Wed 8 Dec - 16:43

debotoijusto wrote:
mutava baštarda wrote:
ljubo1212 wrote:
Noor wrote:
ljubo1212 wrote:4. COVID potvrde - tu nisu imali ništa pametnog za reći, pa su intenciozno i maliciozno fokus prebacili na ženske obline
ne pratiš pozorno ili namjerno preskačeš?

4. COVID potvrde. Rečenica koju prenosite kao lažno evanđelje Vas i Vaših sljedbenika, hraneći pritom ljude nepovjerenjem prema cjepivu, da cijepljeni i necijepljeni jednako prenose virus i da su cijepljeni djelatnici “u velikoj mjeri pridonijeli tim bolničkim infekcijama” je razina zaključka da je vaše pojavljivanje u medijima zadnjih godina u velikoj mjeri doprinijelo većem broju ugrađivanja implantata dojki jer…
Kad Vi ili bilo tko koji će provoditi testiranje cijepljenih i necijepljenih u istraživanje koje se najavljuje među metode rada uvrsti izolaciju virusa, tek tada će moći točno interpretirati rezultate testiranja cijepljenih osoba kod kojih je rezultat testiranja pozitivan na SCoV2 virus i mogućnost da ga prenesu na druge. Osnove virologije i epidemiologije.
Kako objašnjavaš da u Rumunjskoj i Bugarskoj ima najmanje zaraženih u EU, šta kaže struka?
zar nisu oni imali nedavno gadan val ?

Je, to su ravnozemljaši pričali kako će u Rumunja i Bugara pasti, a da će rasti u drugim zemljama, ali tada je to bila hereza. Jer je cijepivo to koje dvadeset puta bolje štiti od širenja zaraze.

by **Hektorović** Wed 8 Dec - 16:43

AssadNaPodmornici wrote:Bogte imaš tri najveća znanstvenika u RH, Lauc, Primorac koji su na istoj razini te mladog znanstvenika Lošu, koji je odličan za svoje godine.

Sa druge strane imaš radikalno lijevi faktograf sa radikalno lijevim novinarima indexa, njihova struka je - srednja stručna sprema ili tečaj marksizma sa fakulteta filozofije /politike.
I naravno ova ekipa radikalnih boljševika određuje što je istina što nije, a još najgore od svega ova tri zema(epi, ljubo, ero) koji su za sebe tvrdili da su desnica /konzervativci na strani su radikalnih boljševika koji ne znaju tablicu množenja kamo da li bi mogli tumačiti znanstvene radove, i tkz konzervativci još jače su protiv slobode izbora i prava pojedinca (što je osnova desne ideologije) nego su na strani represije

Pa zeme će uvijek prilagodljivo uz silu, za silu :) Ideologija je u tom slučaju samo folklor.

by **Hektorović** Wed 8 Dec - 16:44

mutava baštarda wrote:Je, to su ravnozemljaši pričali kako će u Rumunja i Bugara pasti, a da će rasti u drugim zemljama, ali tada je to bila hereza. Jer je cijepivo to koje dvadeset puta bolje štiti od širenja zaraze.

I postavljani su šatori ispred dubrave i to nakon 16 mjeseci pandemije.

by Noor Wed 8 Dec - 16:45

AssadNaPodmornici wrote:da ali neki su sasvim zli.
znamo jednu takvu ovdje

tko, Sorka?
ma nije, ima i ona svijetlih trenutaka :)
samo, voli provocirati

by **Hektorović** Wed 8 Dec - 16:46

Korona novosti i spoznaje - Page 26 211208053.1_xl

Hercegovina :)

by **AssadNaPodmornici** Wed 8 Dec - 16:49

Hektorović wrote:

Hercegovina :)

hahaha samo 10%.. eno svi su pomrli, svim mrtvi. jeste primjetili kako ih ignoriraju mediji

by Guest Wed 8 Dec - 16:50

IVERMECTIN Beats Pfizer And Merck One-Trick-Pony Pills

Pfizer’s new antiviral drug PAXLOVID:tm: shows very high levels of efficacy in preventing serious disease hospitalization and people dying. And that drug works in a particular way, what we call a pharmacodynamic action.
But there’s another generic drug called Ivermectin that you might have heard of that works in exactly the same way as that. Now no one’s saying that information has been deliberately suppressed for years while millions of people have died but what we are going to show on this video is conclusive proof from the literature that this modality of action is the same.
How Coronavirus Infects Its Host
Before we crack into that we need to look at what’s happening so when a virus, in this case coronavirus2 gets into a cell. What happens is it makes lots of proteins. It starts off making these long proteins, out of hundreds of amino acids sometimes. A few thousand amino acids all strung together.
The problem is they’re too long for the job that’s required. So it’s a bit like a building site and when a big log of wood arrives it needs to be trimmed down into bits that fit in your door frames and your window frames. So these proteins need to be trimmed down and it has to be done in a biochemical way.
In the case of coronavirus two, there’s an enzyme called 3CL protease which breaks
down protein into smaller pieces. it’s what we call proteolytic and it will take these long proteins and it will chop them into shorter proteins it’s what we call an endopeptidase. So now instead of having one long protein we’ve got two short ones and these fit together just nicely for the new virus that we’re we’re trying to make.
These new drugs are what we call protease inhibitors because they stop the protease from working. If the protease is like this scissor, the inhibitor is like this tape stopping the cutting up of long proteins.
When there’s another long protein that needs to be processed the 3CL protease comes along ready to chop this up. But now these drugs have bounded up the active site of the protease and they stop the protease from chopping up the big proteins into smaller strings of amino acids. Since they can’t build the virus, it inhibits viral replication.
This is the new Pfizer drug which is designed to block the activity of the sars coronavirus2 3CL, so that 3CL protease now won’t work. It won’t open so i can’t chop my proteins into the correct length to build a nice new virus. And of course a 3CL protease inhibitor will stop it from making sars coronavirus2 and is therefore anti-viral.
Everyone in human biology has heard of chymotryptin. It’s an enzyme released by the pancreas to digest protein. It’s a protein chopping up enzyme so this chymotryptin-like protease inside the virus is working in a very similar way to the chimbotryptin that your pancreas produces to digest your proteins.
Evidence from Pfizer News Release
Pfizer’s novel COVID-19 oral antiviral treatment candidate reduced risk of hospitalization or death by 89% in interim analysis of phase 2/3 EPIC-HR study.

PAXLOVID (PF-07321332; ritonavir) was found to reduce the risk of hospitalization or death by 89% compared to placebo in non-hospitalized high-risk adults with COVID-19
In the overall study population through Day 28, no deaths were reported in patients who received PAXLOVID as compared to 10 deaths in patients who received placebo
Pfizer plans to submit the data as part of its ongoing rolling submission to the U.S. FDA for Emergency Use Authorization (EUA) as soon as possible.

If approved or authorized, PAXLOVID:tm:, which originated in Pfizer’s laboratories, would be the first oral antiviral of its kind, a specifically designed SARS-CoV-2-3CL protease inhibitor. Upon successful completion of the remainder of the EPIC clinical development program and subject to approval or authorization, it could be prescribed more broadly as an at-home treatment to help reduce illness severity, hospitalizations, and deaths, as well as reduce the probability of infection following exposure, among adults. It has demonstrated potent antiviral in vitro activity against circulating variants of concern, as well as other known coronaviruses, suggesting its potential as a therapeutic for multiple types of coronavirus infections.
Evidence for 3CL protease inhibitors from September 2020
Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-Throughput Screening Zhu et al. (Sept 3, 2020)

Viral protease is a valid antiviral drug target for RNA viruses including coronaviruses. (13) In response to the COVID-19 pandemic, great efforts have been made to evaluate the possibility of repurposing approved viral protease inhibitor drugs for the clinical treatment of the disease. Unfortunately, the combination of lopinavir and ritonavir, both approved HIV protease inhibitors, failed in a clinical trial without showing benefit compared to the standard of care. (14) To address this unmet need, several virtual screens and a drug repurposing screen were performed to identify SARS-CoV-2 3CLpro inhibitors.

In conclusion, this study employed an enzymatic assay for qHTS that identified 23 SARS-CoV-2 3CLpro inhibitors from a collection of approved drugs, drug candidates, and bioactive compounds. These 3CLpro inhibitors can be combined with drugs of different targets to evaluate their potential in drug cocktails for the treatment of COVID-19. In addition, they can also serve as starting points for medicinal chemistry optimization to improve potency and drug-like properties.

Ivermectin Emerges as Top Antiviral Candidate for CV2

Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents Mody et al. (2021), source of diagram at top. Excerpts in italics with my bolds.

Fig. 4: Ivermectin exhibited complete inhibition of SARS-CoV-2 3CLpro enzymatic activity whereas micafungin partially inhibited the enzyme

Interestingly, one of the OTD (Off Target Drugs), ivermectin was able to inhibit more than 85% (almost completely) of 3CLpro activity in our in vitro enzymatic assay with an IC50 value of 21 µM. These findings suggest the potential of ivermectin to inhibit the SARS-CoV-2 replication. In support of this, a recent finding suggested that ivermectin (5 µM) inhibited the replication of live SARS-CoV-2 isolated from Australia (VIo1/2020) in Vero/hSLAM cells23. They found that >5000-fold viral counts were reduced in 48 hr in both culture supernatant (release of new virion: 93%) as well as inside the cells (unreleased and unassembled virion: 99.8%) when compared to DMSO treated infected cells.
Earlier studies have demonstrated that the possible anti-viral mechanism of ivermectin was through the blockage of viral-protein transportation to the nucleus by inhibiting the interaction between viral protein and α/β1 importin heterodimer, a known transporter of viral proteins to the nucleus especially for RNA viruses19,20,21,22,23. However, in this study, we have reported that ivermectin inhibits the enzymatic activity of SARS-CoV-2 3CLpro and thus may potentially inhibit the replication of RNA viruses including SARS-CoV-2. These studies suggest that ivermectin could be a potential drug candidate to inhibit the SARS-CoV-2 replication and the proposed anti-viral mechanism of ivermectin presented in Fig. 8 and in vivo efficacy of ivermectin towards COVID-19 is currently been evaluated in clinical trials (ClinicalTrials.gov Identifier: NCT04438850).
Ivermectin Strong Against Multiple Targets

Inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study. Excerpts in italics with my bolds.

In conclusion, both ivermectin and remdesivir could be considered potential drugs for the treatment of COVID-19. Ivermectin efficiently binds to the viral S protein as well as the human cell surface receptors ACE-2 and TMPRSS2; therefore, it might be involved in inhibiting the entry of the virus into the host cell. It also binds to Mpro and PLpro of SARS-CoV-2; therefore, it might play a role in preventing the post-translational processing of viral polyproteins. The highly efficient binding of ivermectin to the viral N phosphoprotein and nsp14 is suggestive of its role in inhibiting viral replication and assembly. Remdesivir may be involved in inhibiting post-entry mechanisms as it shows high binding affinity to N and M proteins, PLpro, Mpro, RdRp, and nsp14. Although the results of clinical trials for remdesivir are promising (Beigel et al., 2020; Wang Y. et al., 2020), similar clinical trials for ivermectin are recommended. Both these drugs exhibit multidisciplinary inhibitory effects at both viral entry and post-entry stages. Source: Molecular Docking Reveals Ivermectin and Remdesivir as Potential Repurposed Drugs Against SARS-CoV-2
Conclusion from John Campbell
So whereas the Pfizer drug is only working as far as we’ve been told in the proviso press release against one biochemical modality of viral replication, the Ivermectin mechanism is working at many different levels. The fact that the the the Pfizer medicine is only working against one particular biochemical pathway means to me that the virus could learn to avoid that. It could evolve to be drug resistant as indeed the early antiretrovirals did with HIV.
With ivermectin, because it’s working on so many different levels, it is improbable, to put it mildly,that a virus would mutate in a dozen different ways to avoid all those different mechanisms. We’ve talked about six mechanisms today. It’s very unlikely that we get six mutations that could dodge all of those all at the same time.

So I’ve a brief message to world leaders, people that are making the decisions about this. Come on you all, you’re not a horse and you’re not a cow. You’ve got a human intellect. Let’s use it to follow the scientific evidence to save human pain, suffering and death.

Footnote: This video focused on Pfizer’s pill, but Merck’s Molnupiravir pill is also a one-trick-pony. See Why Merck Dissed Its Own Invention Ivermectin

https://rclutz.com/2021/11/27/ivm-beats-pfizer-and-merck-one-trick-pony-pills/

by Guest Wed 8 Dec - 16:51

by **Hektorović** Wed 8 Dec - 16:52

AssadNaPodmornici wrote:
Hektorović wrote:

Hercegovina :)
hahaha samo 10%.. eno svi su pomrli, svim mrtvi. jeste primjetili kako ih ignoriraju mediji

Široki danas

Korona novosti i spoznaje - Page 26 635910975427054576-The-Walking-Dead-zombies

by mutava baštarda Wed 8 Dec - 16:52

Hektorović wrote:

Hercegovina :)

Jači od sinjskog Otoka i Dicma
:cro

by Noor Wed 8 Dec - 16:59

Hektorović wrote:

Široki danas

...a zeme sutra

by **Hektorović** Wed 8 Dec - 17:06

100%

#PfizerSays #PandemicReporting #PressReleaseJournalism https://t.co/IQ6fka0hb3
— Paul D. Thacker (@thackerpd) November 24, 2021

by debotoijusto Wed 8 Dec - 17:09

AssadNaPodmornici wrote:
debotoijusto wrote:
AssadNaPodmornici wrote:Bogte imaš tri najveća znanstvenika u RH, Lauc, Primorac koji su na istoj razini te mladog znanstvenika Lošu, koji je odličan za svoje godine.

Sa druge strane imaš radikalno lijevi faktograf sa radikalno lijevim novinarima indexa, njihova struka je - srednja stručna sprema ili tečaj marksizma sa fakulteta filozofije /politike.
I naravno ova ekipa radikalnih boljševika određuje što je istina što nije, a još najgore od svega ova tri zema(epi, ljubo, ero) koji su za sebe tvrdili da su desnica /konzervativci na strani su radikalnih boljševika koji ne znaju tablicu množenja kamo da li bi mogli tumačiti znanstvene radove, i tkz konzervativci još jače su protiv slobode izbora i prava pojedinca (što je osnova desne ideologije) nego su na strani represije

jebote ka da pricas o mladom gvardiolu a ne iscjedku domazet loso uhljebljenom na drzavnoj sisi i odrastao u okruzenju price o treceg sv. rata koji zapoceo 2021 na jadranu
od kad si popusio budalastinu ukralo od ruzicastog plamenca srljas u nove urote nije ti to dobro za mlad organizam

za Primorca i Lauca znam da su jebeni stručnjaci, zapravo možda i najveći u državi.
Lošo, Lauc je za njega rekao da je imao pravo kada je rekao da su cijepiva genetska terapija, da nisu klasična cijepiva.
Sigurno više vjerujem Laucu , nego tebi sa srednjom stručnom spremom, novinari indexa sa srednjom stručnom spremom ili boljševiku sa Faktografa koji ima fakultet filozofije marksizma, te vjernim pratiteljima, poput tebe, epija, ere, itd

nisam se osvrnuo na lauca nego losu no nebitno
jel ovo taj lauc sveznajuci

Lauc kaže kako većina ljudi ne zna razliku između virusa i bakterija te napominje kako su ospice puno zaraznije od covida-19, a smrtnost im je podjednaka. Otprilike 1 na tisuću zaraženih kod ospica, a kod SARS-CoV-2 nešto više, s time da su za osobe mlađe od 80 godina ospice puno smrtonosnije od COVID-19.

Dakle da nas većina nije cijepljena protiv ospica, pandemija ospica bi bila puno strašnije od panedmije SARS-CoV-2. I protiv SARS-CoV-2 dolazi cjepivo za nekoliko mjeseci, tako da je ova priča s pandemijom sigurno gotova na proljeće - zaključuje znanstvenik.

29.11.2020

by **AssadNaPodmornici** Wed 8 Dec - 17:12

Lauc je imao par svojih grešaka, i lik se ispričao za greške, naveo je razlog greške itd.

luđake koji su tebi uzor, poput ere, ili ekipe sa srednjom stručnom spremom aka novinara/faktografa, ili "znanstvenika" bez jednog znanstvenog rada koje isti novinari sa srednjom stručnom spremom pitaju za mišljenje, takvi nabrojani luđaci griješe na dnevnoj razini

a onda se uzme Laucu neka greška prije godinu dana
ili Bakiću da mu je model falio za 15%, dok imamo stotine fizičara/matematičara na državnoj sisi nisu izbacili niti jedan jedini model, a država pošto nije uzela Bakićev model(koji je odlično pogodio vrh pandemije a falio za 15ak% mrtvih i hospitalizacije ) , mogla je uštedjeti pola eskadrile aviona

by **AssadNaPodmornici** Wed 8 Dec - 17:14

recimo luđaci iz države su opet "dizali" šatore ispred svake bolnice , međutim da su pogledali na Bakićev(Laucov model mogli su skužitii da neće biti potrebe za tim

a oni su slušali te navedene stručnjake, ere, novinare, faktografe, koji su tvrdili da će nakon utakmice HR_RU gdje je pola hercegovine došlo na stadion(neka su), provjeda u ZGu i parade u Vukovaru biti kolaps sustava.
haha
stručnjaci

by newuser Wed 8 Dec - 17:16

Hektorović wrote:

Hercegovina :

kakvi su podatci za BiH, pogotovo za hercegovinu s obzirom na 10 -12 % cijepljenih trebala bi biti ogromna smrtnost po nasim forumskim expertima.

by newuser Wed 8 Dec - 17:20

newuser wrote:
Hektorović wrote:

Hercegovina :
kakvi su podatci za BiH, pogotovo za hercegovinu s obzirom na 10 -12 % cijepljenih trebala bi biti ogromna smrtnost po nasim forumskim expertima.

Nasao sam, 25 oboljelih u zapadnohercegovackoj zupaniji. Na nekih 90.000 ljudi.
Sta kazes Ero, puno?

by debotoijusto Wed 8 Dec - 17:26

AssadNaPodmornici wrote:Lauc je imao par svojih grešaka, i lik se ispričao za greške, naveo je razlog greške itd.

luđake koji su tebi uzor, poput ere, ili ekipe sa srednjom stručnom spremom aka novinara/faktografa, ili "znanstvenika" bez jednog znanstvenog rada koje isti novinari sa srednjom stručnom spremom pitaju za mišljenje, takvi nabrojani luđaci griješe na dnevnoj razini

a onda se uzme Laucu neka greška prije godinu dana
ili Bakiću da mu je model falio za 15%, dok imamo stotine fizičara/matematičara na državnoj sisi nisu izbacili niti jedan jedini model, a država pošto nije uzela Bakićev model(koji je odlično pogodio vrh pandemije a falio za 15ak% mrtvih i hospitalizacije ) , mogla je uštedjeti pola eskadrile aviona

kolega @ero je ti samo sa druge strane spektra
zbog dostupnosti brza interneta napravili ste filozofiju od virusa koji se zgotovi disciplinom ( peres ruke ne guzvas se u zatvorenom distanca ...) i cjepivom u konacnici
jebote tablete za goveda zagovarate :facepalm

neobrazovana bahatost sto zaziva susramlje

by Guest Wed 8 Dec - 17:29

debotoijusto wrote:
AssadNaPodmornici wrote:Lauc je imao par svojih grešaka, i lik se ispričao za greške, naveo je razlog greške itd.

luđake koji su tebi uzor, poput ere, ili ekipe sa srednjom stručnom spremom aka novinara/faktografa, ili "znanstvenika" bez jednog znanstvenog rada koje isti novinari sa srednjom stručnom spremom pitaju za mišljenje, takvi nabrojani luđaci griješe na dnevnoj razini

a onda se uzme Laucu neka greška prije godinu dana
ili Bakiću da mu je model falio za 15%, dok imamo stotine fizičara/matematičara na državnoj sisi nisu izbacili niti jedan jedini model, a država pošto nije uzela Bakićev model(koji je odlično pogodio vrh pandemije a falio za 15ak% mrtvih i hospitalizacije ) , mogla je uštedjeti pola eskadrile aviona
kolega @ero je ti samo sa druge strane spektra
zbog dostupnosti brza interneta napravili ste filozofiju od virusa koji se zgotovi disciplinom ( peres ruke ne guzvas se u zatvorenom distanca ...) i cjepivom u konacnici
jebote tablete za goveda zagovarate neobrazovana bahatost sto zaziva susramlje

debilu pročitaj moja dva posta iznad i pogledaj i poslušaj video i susramljuj se ti glupane.

by debotoijusto Wed 8 Dec - 17:39

Gnječ wrote:
debotoijusto wrote:
AssadNaPodmornici wrote:Lauc je imao par svojih grešaka, i lik se ispričao za greške, naveo je razlog greške itd.

luđake koji su tebi uzor, poput ere, ili ekipe sa srednjom stručnom spremom aka novinara/faktografa, ili "znanstvenika" bez jednog znanstvenog rada koje isti novinari sa srednjom stručnom spremom pitaju za mišljenje, takvi nabrojani luđaci griješe na dnevnoj razini

a onda se uzme Laucu neka greška prije godinu dana
ili Bakiću da mu je model falio za 15%, dok imamo stotine fizičara/matematičara na državnoj sisi nisu izbacili niti jedan jedini model, a država pošto nije uzela Bakićev model(koji je odlično pogodio vrh pandemije a falio za 15ak% mrtvih i hospitalizacije ) , mogla je uštedjeti pola eskadrile aviona
kolega @ero je ti samo sa druge strane spektra
zbog dostupnosti brza interneta napravili ste filozofiju od virusa koji se zgotovi disciplinom ( peres ruke ne guzvas se u zatvorenom distanca ...) i cjepivom u konacnici
jebote tablete za goveda zagovarate neobrazovana bahatost sto zaziva susramlje

debilu pročitaj moja dva posta iznad i pogledaj i poslušaj video i susramljuj se ti glupane.

ako vam ne ukinu internet ovo nikad nece zavrsit nesrico

by Eroo Wed 8 Dec - 17:40

POSTUPNO OTVARANJE
Austrija se u nedjelju otvara ali samo za cijepljene, necijepljeni i dalje ostaju u lockdownu

https://www.vecernji.hr/vijesti/austrija-12-12-ukida-lockdown-i-policijski-sat-za-cijepljene-samo-tri-pokrajine-potpuno-otkljucane-1545759

_____________________________________________

Žaba samo što nije skuhana, pozvani ste na gozbu... :^0

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